Attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are frequent, chronic and highly heritable neurodevelopmental disorders. Despite their societal importance, progress in understanding disease biology has been slow and no curative treatment options are available.
The pan-European training network MiND aims to educate a new generation of researchers in the field of neurodevelopmental disorders, through innovation-oriented research combined with highly interdisciplinary and intersectoral international training.
»Knowledge about aggression aetiology is limited and current treatment strategies are insufficient.«
Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime.
Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental subtypes, we investigate the aetiology of maladaptive aggression in paediatric conduct disorders most strongly predisposing to pathological aggression, Attention-deficit Hyperactivity Disorder (ADHD) and Conduct Disorder (CD), and in the general population.
More than 21 million people suffer from ADHD in the EU, with direct medical cost and loss due to decreased productivity adding up to over €70 billion per year. ADHD, being a childhood-onset disorder, forms the entry route into a (preventable) negative developmental trajectory later in life; importantly, more than 80% of adult ADHD patients suffer from a comorbid disorder. However, exact numbers of ADHD patients suffering from the comorbidities under study is not yet available. CoCA will provide such information, based on large epidemiological data sets, and – for the first time – will calculate the costs associated with such comorbidity. Through the research approaches taken in CoCA, we hope to raise awareness for ADHD, reduce the stigma associated with this disorder, and empower prevention and therapy approaches.
The FemNAT-CD study is an exciting new European project that aims to understand the causes of sex differences in behaviour. FemNAT-CD is a multi-disciplinary study that will recruit 1,840 children and teenagers aged from 9 to 18 years from across Europe (including the UK, Germany, Ireland, Switzerland, the Netherlands, Spain, Greece and Hungary). The project will study similarities and differences between boys and girls in brain structure and function, hormone levels, genetics, emotion recognition and regulation, and physiological activity. We will also be conducting interviews with children and their parents to ask about the child’s health and behaviour, and trying to understand the impact of environmental factors on well-being.
The overarching goal of this ECNP Network is to bring together excellent clinical and basic researchers across disciplines from Europe and beyond, to study the etiology of ADHD across the lifespan – i.e., from childhood through adolescence to adulthood and, finally, senescence – in order to enable progress in clinical strategies of ADHD diagnosis, prognosis and treatment. Importantly, this will also result in a reduction of the societal burden brought about by the disorder in all stages of the lifespan.
IMpACT, short for ‘International Multi-centre persistent ADHD CollaboraTion’, is a consortium of clinical and basic researchers from several European countries (The Netherlands, Germany, Spain, Norway, The United Kingdom, Sweden), from the United States of America and from Brazil.
The mission of IMpACT is to perform and promote high quality research in ADHD across the lifespan. This research is aimed at identifying novel genetic variants for adult ADHD and at understanding the mechanisms underlying the effect of these genetic variants on disease risk. IMpACT members share data on their samples as well as biological material, which has resulted in the formation of the largest database for adult ADHD research, including information on over 4000 cases and more than 7000 controls.
The best return on our research investments will come from combining our data to achieve the large samples necessary to detect the modest gene effect sizes that we now know are the rule rather the exception for complex traits.
The ENIGMA Network has several goals:
The Johannes Gutenberg University Mainz and the Goethe University Frankfurt have both selected neuroscience as their research focus and have signed a contract of cooperation in the biomedical sciences to this end.
The contract will ensure an aligned strategic plan in developing neurosciences at both locations. Specifically, the contract guarantees harmonization of the hiring strategy, enables researchers and students alike to utilize facilities at both institutions, and provides the formal basis for common research activities such as CRCs or CRUs.
Researchers in the neurosciences from the Johannes Gutenberg University Mainz and the Goethe University Frankfurt, the Max-Planck-Institutes for brain research and biophysics, the Institute for Molecular Biology Mainz, Frankfurt Institute for Advanced Studies (FIAS) and the Ernst Strüngmann Institute have established the Rhine-Main Neuroscience Network (rmn²). Expertise in molecular-, cellular-, and systems neuroscience is the hallmark of rmn².
Das IZNF ist ein Zusammenschluss von über 50 neurowissenschaftlich arbeitenden Forschergruppen in Frankfurt. Beteiligt sind neben den 6 universitären Fachbereichen Medizin, Biowissenschaften, Psychologie und Sportwissenschaften, Chemische und Pharmazeutische Wissenschaften, Mathematik und Physik auch das Max-Planck-Institut für Hirnforschung, das Max-Planck-Institut für Biophysik, das Frankfurt Institute for Advanced Studies (FIAS) und das Ernst-Strüngmann-Institut (ESI).
· Das IZNF steht für die Förderung des Austauschs und der Zusammenarbeit der Mitglieder aus den verschiedenen Fachgebieten z. B. bei der Erforschung von Alzheimer, Multiple Sklerose, Parkinson oder des Themas Altern.
· Das IZNF fördert das Gesehenwerden des Neuro-Standorts Frankfurt z. B. durch regelmäßige Vorträge für die an Hirnforschung interessierte Öffentlichkeit.
· Das IZNF betreibt Nachwuchsförderung inklusive Einrichtung eines neuen Master Neuroscience Studiengangs und unterstützt die
· internationale Kooperation auf dem Gebiet der Neurowissenschaft.